Motoneurone Disease Stroke Peripheral Neuropathy Multiple Sclerosis
Drug Platform Publications Collaborations
Our Mission Management Team Advisory Boards


CuroNZ News

CuroNZ is pleased to report high level pre-clinical results achieved in patient dog studies in collaboration with Dr Roger Clemmons, Associate professor of Neurology for animals at the University of Florida.  He has applied intra-muscular NRP injections to several patient dogs suffering from spinal cord injury, eye diseases and the dog equivalent of progressive Multiple Sclerosis (degenerative myelopathy). 

We have uploaded a video of ‘Buc’ the dog who has spinal cord injury and the dog equivalent of retinitis pigmentosa, the video shows before and after NRP walking, gait and movement.  Click to view Video. 

Since having NRP injections Buc's eyesight has not deteriorated as would normally be expected in this timeframe and as you can see on the video his gait and walking is much improved.

Background to the NRP Discovery

  • The first discovered NRP derived from an in vitro cultivated rat brain cell tissue.
  • Specialised biochemical fractionation of the metabolized cell nutrients led to the discovery of a neuronal proliferation and migration-inducing activity.
Migrating Neurons

Diagram showing cerebellar CNS tissue cultivated for 48 hrs without NRPs (A) and with NRPs (B). Note the remarkable increase in the formation of cell-bridges (migrating neurons) as been highlighted by the opposing arrows in B. Moreover, there are new nerve fibre connections between tissues (single arrow).

  • As far as we are aware, never before has it been possible to induce neurogenesis and final differentiation of neuroblasts (cells that are about to acquire status of action potential-firing neurons incorporated into an active neural network) within highly differentiated brain tissue.
  • This is especially so  when the cultivated central nervous system-derived brain cells have been extracted from postnatally reared rodents.
  • The subsequently purified “activity” turned out to be a small secreted peptide.NRP Discovery
  • Using bioinformatic approaches several human homologues similar to the rat peptide have been identified.

Click on the following aspects of the NRP drug platform to read more: