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CuroNZ News

CuroNZ is pleased to report high level pre-clinical results achieved in patient dog studies in collaboration with Dr Roger Clemmons, Associate professor of Neurology for animals at the University of Florida.  He has applied intra-muscular NRP injections to several patient dogs suffering from spinal cord injury, eye diseases and the dog equivalent of progressive Multiple Sclerosis (degenerative myelopathy). 

We have uploaded a video of ‘Buc’ the dog who has spinal cord injury and the dog equivalent of retinitis pigmentosa, the video shows before and after NRP walking, gait and movement.  Click to view Video. 

Since having NRP injections Buc's eyesight has not deteriorated as would normally be expected in this timeframe and as you can see on the video his gait and walking is much improved.

Collaborations between CuroNZ and academic institutions:

Leibniz- Institute for Neurobiology  (IFN) in Magdeburg, Germany

  • This government funded institution is one of the largest Neuroscience centres in Germany conducting basic research in the areas of memory formation, synaptic plasticity and regeneration crucial for the functioning and maintenance of neural networks.
  • There is a high level of ongoing collaboration with Prof Klaus G. Reymann and his lab.
  • Prof Reymann is one of the pioneers in the field of Long-Term Potentiation (LTP), representing the first well validated process involved in building memory traces in mammals.
  • He is also the founder of the biotechnology company FAN GmbH, based in Magdeburg. FAN GmbH provides high-end technical services regarding CNS-based animal models and develops relevant neuronal in vitro systems as screening tools for the pharmaceutical industry in Europe.
  • We receive  invaluable scientific recommendations in the area of Neuroscience from Prof Reymann. He is a member of the scientific advisory board of CuroNZ.

National Stroke Research Institute and University of Melbourne Department of Medicine, Austin Health, Australia

  • This major teaching hospital, together with the National Stroke Research Institute (NSRI), is one of the main centres for CNS trauma and stroke recovery in Australia.
  • Basic research and clinical applications are interconnected in this research hospital to bring new therapeutic strategies quicker into clinical settings for the benefit of the patients.
  • Associate Prof. David Howells and his team are in close collaboration with  CuroNZ. David Howells is an internationally acclaimed expert in the field of stroke research. Potential drug-related regenerative processes are monitored in his group by using animal models mimicking stroke and spinal cord injury.
  • In particular, his profound knowledge in assessing new drug candidate’s abilities for promoting neural regeneration is of real  value to CuroNZ for its ongoing  drug development strategy.
  • David Howells is a member of the scientific advisory board of CuroNZ.

University of Cagliari, Department of Anatomy, Sardegna, Italydna

  • The University of Cagliari with its Department of Anatomy is known for its research excellence in the field of determination of human embryonic stem cell (hESC) origin, its fate during organ development and its potential ability for trans-differentiation from one cell type to another. 
  • Associate Prof. Andrea Diana oversees the team responsible for hESC research. He also collaborates with CuroNZ.
  • This collaboration enables the testing of  NRP’s capability in exerting its activity on human neural stem cells, a pre-requisite step before the NRP lead compound can enter clinical development. 
  • Apart from biological activity testing Andrea Diana’s group is involved in mechanism of action studies to unravel the intracellular pathway of NRP’s activity profile.
  • Andrea Diana is a member of the scientific advisory board of CuroNZ.