Motoneurone Disease Stroke Peripheral Neuropathy Multiple Sclerosis
Drug Platform Publications Collaborations
Our Mission Management Team Advisory Boards


CuroNZ News

CuroNZ is currently in search of additional funding to enable completion of  the preclinical phase of drug development for NRPs, with the particular initial targets being Multiple Sclerosis and Motoneurone Disease (ALS)

Since these diseases have few effective treatments, drugs which have potential for the disease are eligible to be  granted Orphan Drug Status by the FDA.

If granted, Orphan Drug status has many benefits including significantly reducing the time and cost of a drug's clinical development.

The other FDA Orphan Drug incentives are significant and include grant money, tax rebates, 7 year market exclusivity of the drug and assistance with the clinical development strategy.

Peer Reviewed Publications, that CuroNZ Director, Dr Sieg has contributed to:

  • A. T. Singh, J. A. Keelan, F. Sieg (2010).  Regulation of trophoblast migration and survival by a novel neural regeneration peptide (NRP). RBM online accepted, 2010.
  • M.J. Bickerdike, G.B. Thomas, D.C. Batchelor, E.S. Sirimanne, W. Leong, H. Lin, F. Sieg, J. Wen, M.A. Brimble, P.W. Harris, P.D. Gluckman (2009). NNZ-2566: A Gly-Pro-Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke. Journal of Neurological Sciences 278: 85-90. Publications
  • F. Sieg and A. Antonic (2007) Alternative Strategies in Neuroregeneration and Neurogenesis. Research signpost edition (book chapter). Editor: Valeria Sogos and Andrea Diana; pp: 27-58.
  • T. Gorba, P. Bradoo, A. Antonic, K. Marvin, D.-X. Liu,  P. Lobie, K. Reymann, P.D. Gluckman and F. Sieg (2006) Neural Regeneration Proteins are novel chemoattractive and survival promoting peptides. Exp. Cell Research.,  312: 3060-3074.
  • J. Guan, S. Mathai, F. Sieg, T. Gorba, M.A. Brimble, P.D. Gluckman (2005). Neuroprotective effects of diketopiperazines, potential clinical application of small cyclic form of neuropeptide following ischemic brain injury. Journal of Cerebral Blood Flow & Metabolism 25, S54.
  • P. Landgraf, F. Sieg, G. Meyer, P. Wahle, H.-C. Pape and M. R. Kreutz (2005) A maternal blood-borne factor promotes survival of the developing thalamus. FASEB J. 19: 225-227.
  • M.A. Brimble, N.S. Trotter, P.W.R. Harris and F. Sieg (2005). Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L-glutamic acid (GPE) modified at the alpha-carboxylic acid.  Bioorg Med Chem 13: 501-519.
  • M.A. Brimble, N.S. Trotter, P.W.R. Harris and F. Sieg (2005). Synthesis and pharma- cological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE). Bioorg Med Chem 13: 519-532.
  • M.Y.H. Lai, M.A. Brimble, D.J. Callis, P.W.R. Harris, M. S. Levi and F. Sieg (2005). Synthesis and pharmacological evaluation of glycine-modified analogues of the neuro- protective agent glycyl-L-prolyl-L-glutamic acid (GPE). Bioorg Med Chem 13: 533-548.
  • H.A. Sror, G. Tischendorf, F.Sieg, J.M. Schmitt and D.K. Hincha (2003). Cryoprotectin protects thylakoids during a freeze-thaw cycle by a mechanism involving stable membrane binding. Cryobiology  47: 191-203.
  • W.E. Wilhemi, U.H. Schroeder, A. Benabdallah, F. Sieg, J. Breder and K.G. Reymann (2002). Organotypic brain-slice cultures from adult rats: approaches for a prolonged culture time. ATLA 30: 275-283.Peer reviewed journal articles
  • D.K. Hincha, B. Neukamm, H.A.M. Sror, F. Sieg, W. Weckwrath, M. Rueckels, V. Lullien-Pellerin, W. Schroeder and J.M. Schmitt (2001). Cabbage cryoprotectin is a member of the nonspecific plant lipid transfer protein gene family. Plant Physiology 125: 835-846.
  • T. Budde, F. Sieg, K.-H. Braunewell, E. Gundelfinger, H.-C. Pape (2000). Calcium-induced calcium release maintains the relay mode of activity in thalamocortical cells. Neuron 26:483-492.
  • F. Sieg, P. Wahle and H.-C.Pape (1999). Cellular reactivity to mechanical axonal injury in an organotypic in vitro model of neurotrauma . Journal of Neurotrauma 16: 1099-1115.
  • F. Sieg, K. Obst, T. Gorba, B. Riederer, H.-C. Pape and P. Wahle (1998). Postnatal expression pattern of calcium-binding proteins in organotypic thalamic cultures and in the dorsal thalamus in vivo. Developmental Brain Research 110:83-95.
  • D.K. Hincha, F. Sieg, I. Bakaltcheva, H. Köth and J.M. Schmitt (1996). Freeze-thaw damage to thylakoid membranes: specific protection by sugars and proteins. Book title: "Advances in low-temperature biology", Vol.3, chapter 4, JAI Press Inc.
  • F. Sieg, W. Schröder, J.M. Schmitt and D.K. Hincha (1996). Purification and characterisation of a cryoprotective protein (cryoprotectin) from leaves of cold-acclimated cabbage. Plant Physiology 111: 215-221.
  • F. Sieg, J.M. Schmitt and D.K. Hincha (1994). Cryoprotective leaf proteins: Purification and partial characterisation. Cryo-Letters 14: 1-15.